Buy Clomipramine (Anafranil) Cas 303-49-1

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).^[7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania,^[8] body dysmorphic disorder^[9][10][11] and chronic pain.^[7] It has also been notably used to treat premature ejaculation^[7] and the cataplexy associated with narcolepsy.^[12][13]

It may also address certain fundamental features surrounding narcolepsy besides cataplexy (especially hypnagogic and hypnopompic hallucinations).^[14] The evidence behind this, however, is less robust. As with other antidepressants (notably including selective serotonin reuptake inhibitors), it may paradoxically increase the risk of suicide in those under the age of 25, at least in the first few weeks of treatment.^[7]

It is typically taken by mouth, although intravenous preparations are sometimes used.^[15][16]

Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating.^[7] Serious side effects include an increased risk of suicidal behavior in those under the age of 25, seizures, mania, and liver problems.^[7] If stopped suddenly, a withdrawal syndrome may occur with headaches, sweating, and dizziness.^[7] It is unclear if it is safe for use in pregnancy.^[7] Its mechanism of action is not entirely clear but is believed to involve increased levels of serotonin and norepinephrine.^[7]

Clomipramine was discovered in 1964 by the Swiss drug manufacturer Ciba-Geigy.^[17] It is on the World Health Organization’s List of Essential Medicines.^[18] It is available as a generic medication.^[7]

Clomipramine has a number of uses in medicine, including in the treatment of:

• Obsessive–compulsive disorder (OCD), which happens to be its only US FDATooltip Food and Drug Administration-labeled indication.^[19][20] Other regulatory agencies (such as the TGA of Australia and the MHRA of the UK) have also approved clomipramine for this indication.^{[21][22][23][24]}
• Major depressive disorder (MDD), a popular off-label use in the US. It is approved by the Australian TGA and the United Kingdom MHRA for this indication. In Japan it is also approved for depression.^{[21][22][23][24][25][26]} Some have suggested the possible superior efficacy of clomipramine compared to other antidepressants in the treatment of MDD,^{[27][28][29][30][31]} especially the more severe,^[32][33][34] although at the current time the evidence may be insufficient to more fully substantiate this claim.^[35]

As-with other tricyclic antidepressants, the antidepressant response specifically may be augmented, including in treatment-resistant cases, with triiodothyronine, at a dosage of 50 mcg.^{[36][37][38][39]} In the case of clomipramine specifically, this may also be the case with obsessive-compulsive disorder.^[40]