Buy Vilazodone (Viibryd) Cas 163521-12-8

Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder.^[1] It is classified as a serotonin modulator^[1] and is taken by mouth.^[1]

Its common side effects include nausea, diarrhea, and trouble sleeping.^[1] Serious side effects may include increased suicidal thoughts or actions in those under the age of 25, serotonin syndrome, bleeding, activation of mania or hypomania, pancreatitis, seizures, angle-closure glaucoma, sleep paralysis, and sexual dysfunction.^[6]

Vilazodone may cause a syndrome of inappropriate antidiuretic hormone secretion (SIADH).^[1] A withdrawal syndrome may occur if the dose is rapidly decreased.^[1] Use during pregnancy and breastfeeding is not generally recommended.^[7] It is in the serotonin modulator class of medications and is believed to work both as a selective serotonin reuptake inhibitor (SSRI) and activator of the 5-HT_1A receptor.^[1]

Vilazodone was approved for medical use in the United States in 2011^[1] and in Canada in 2018.^[8] In 2019, it was the 334th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.^[9] The drug lost patent protection in June 2022 for adults and in July 2023 for pediatrics.^[10] Generic versions have been approved by the US Food and Drug Administration.^[11]^[12]

Medical uses

Seven controlled efficacy trials were conducted of vilazodone for treatment of major depressive disorder.^[13] Five of these trials showed no significant influence of vilazodone over placebo on depressive symptoms.^[13] In the remaining two trials, small but significant advantages of vilazodone over placebo were found.^[13]^[14] According to these two eight-week trials in adults, vilazodone has an antidepressant response after one week of treatment.^[15] After eight weeks it resulted in a 13% greater response than placebo.^[15] Remission rates, however, were not significantly different versus placebo.^[15]

According to the US Food and Drug Administration (FDA) in 2011, “it is unknown whether vilazodone has any advantages compared to other drugs in the antidepressant class.”^[16] A 2019 review stated that “present studies do not suggest the superiority of vilazodone compared with other antidepressants.”^[17]

Development of vilazodone for generalized anxiety disorder has been stopped as of 2017.^[18] While there is tentative evidence of a small benefit in generalized anxiety disorder, there is a high rate of side effects.^[19]

Adverse effects

In September 2016, the US Food and Drug Administration (FDA) required a new warning to be added to the prescribing information related to a link between vilazodone and acute pancreatitis and sleep paralysis.^[20] In addition, other sleep disturbances such as hypnagogic hallucinations and sleep terrors can occur.^[21]^[22]

Sleep paralysis is a state, during waking up or falling asleep, in which a person is conscious but experiences full-body paralysis. During an episode, the person may hallucinate (hear, feel, or see things that are not there), which often results in fear.^[23] A night terror, also called sleep terror, is a sleep disorder causing feelings of panic or dread.^[24] The rate of sleep paralysis adverse events was high enough to merit an FDA warning added to the Viibryd prescription label.

Buy Vilazodone (Viibryd) Cas 163521-12-8

VILAZODONE

Product Description:
Product Name: VILAZODONE CAS NO: 163521-12-8

Synonyms:

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;

2-BenzofurancarboxaMide,5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-;

Vilazodonei;Vilazodone5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide;

Chemical & Physical Properties:

Appearance: Light yellow solid

Assay :≥98.00%

Density: 1.34 g/cm3

Boiling Point: 745.1℃ at 760 mmHg

Melting Point: 203-205℃

Storage Temp.: Refrigerator

Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo. It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

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VILAZODONE structure

CAS No.: 163521-12-8

Chemical Name:: VILAZODONE

Synonyms: Vilazodone HCL;CS-108;AK-Con;All Clear;Vilozodone;VILAZODONE;EMD 515259;Clear Eyes;Velazolone;Vilazodonei

CBNumber:: CB31011682

Molecular Formula:: C26H27N5O2

Molecular Weight:: 441.52

MDL Number:: MFCD09838919

MOL File:: 163521-12-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Vilazodone 99.73%	CS-0550	5mg	$166
Vilazodone 99.73%	CS-0550	10mg	$258
Vilazodone 99.73%	CS-0550	25mg	$363
Vilazodone 99.73%	CS-0550	50mg	$429
Vilazodone	A3918	10mg	$180
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VILAZODONE Properties

Melting point	203-205°C
Boiling point	745.1±60.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly)), Methanol (Slightly)
pka	15.98±0.30(Predicted)
form	Solid
color	Pale Yellow to Beige
Stability	Very Hygroscopic
InChIKey	SGEGOXDYSFKCPT-UHFFFAOYSA-N
SMILES	O1C2=CC=C(N3CCN(CCCCC4C5=C(NC=4)C=CC(C#N)=C5)CC3)C=C2C=C1C(N)=O
CAS DataBase Reference	163521-12-8
FDA UNII	S239O2OOV3
ATC code	N06AX24

SAFETY

Risk and Safety Statements

Hazardous Substances Data	163521-12-8(Hazardous Substances Data)

VILAZODONE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0550	Vilazodone 99.73%	163521-12-8	5mg	$166	2026-06-04	Buy
ChemScene	CS-0550	Vilazodone 99.73%	163521-12-8	10mg	$258	2026-06-04	Buy
ChemScene	CS-0550	Vilazodone 99.73%	163521-12-8	25mg	$363	2026-06-04	Buy
ChemScene	CS-0550	Vilazodone 99.73%	163521-12-8	50mg	$429	2026-06-04	Buy
ApexBio Technology	A3918	Vilazodone	163521-12-8	10mg	$180	2026-05-06	Buy

VILAZODONE Chemical Properties, Uses, Production

Description

Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.

References

https://www.drugbank.ca/drugs/DB06684
https://en.wikipedia.org/wiki/Vilazodone
http://www.rxlist.com/viibryd-drug/indications-dosage.htm

Description

In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC₅₀=0.2 nM) with high affinity for 5-HT1A receptors (IC₅₀=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.

Chemical Properties

Light Yellow Solid

Originator

Merck KGaA (Germany)

Uses

It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Uses

Labelled analogue of Vilazodone

Uses

An inhibitor of ST and activator of SR-1A

Definition

ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.

brand name

Viibryd

Mechanism of action

The mechanism of action of Vilazodone antidepressant is to enhance the release of serotonin from the serotonergic pathway in the brain by inhibiting the serotonin transporter (similar to a selective serotonin reuptake inhibitor (SSRI)) while stimulating the serotonin-1a receptor through partial agonism. Its agonistic effects are similar to those of the anxiolytic drug buspirone.

Side effects

The most common side effects of Vilazodone administered orally include: diarrhoea, dizziness, headache, dry mouth, nausea, vomiting, and sleep disturbances. These symptoms are mild and may disappear within a few days or weeks. Other serious side effects that may occur include: bleeding, hyponatraemia (low levels of sodium in the blood, manifested by dizziness, light-headedness, difficulty concentrating and fainting), mania, seizures (loss of consciousness, twitching of limbs), closed-angle glaucoma (sudden eye pain or loss of vision) and allergic reactions. Seek medical attention if any of these serious adverse symptoms occur.

VILAZODONE synthesis

Synthesis of VILAZODONE from 3-(4-Chlorbutyl)-1H-indol-5-carbonitril and 5-piperazin-1-yl-1-benzofuran-2-carboxamide

VILAZODONE Preparation Products And Raw materials

Vilazodone | CAS 163521-12-8 | SCBT – Santa Cruz Biotechnology

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VILAZODONE (CAS 163521-12-8) information, including chemical properties, structure, melting point, boiling point, …
- Boiling point: 745.1±60.0 °C (Predicted)
- Melting point: 203-205°C
- Density: 1.34±0.1 g/cm3 (Predicted)
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Chemical name:Vilazodone ; CAS NO:163521-12-8; Molecular Formula:; Molecular Weight:441.5323; EINECS:

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