Buy Edivoxetine (LY-2216684) Cas 1194508-25-2

Buy Edivoxetine (LY-2216684) Cas 1194508-25-2

Edivoxetine (INN; code name LY-2216684) is a drug which acts as a selective norepinephrine reuptake inhibitor and was under development by Eli Lilly for attention-deficit disorder (ADD) and as an antidepressant treatment.^[1][2] It was in phase III clinical trials in 2012 for major depressive disorder, but failed to get approval.^[1][3]

In a study published in 2010, edivoxetine succeeded to prove superiority over placebo, as measured by Hamilton Depression Rating Scale. However, effectiveness could be observed using the Self-Rated Quick Inventory of Depressive Symptomatology.^[4]

In a study published in 2011, using the Montgomery–Åsberg Depression Rating Scale and the Sheehan Disability Scale, edivoxetine showed superiority over placebo, with higher response and remission rates.^[5]

In December 2013, Eli Lilly announced that the clinical development of edivoxetine will be stopped due to lack of efficacy compared to SSRI alone in three separate clinical trials.^[6]

Side effects significantly associated with edivoxetine are headache, nausea, constipation, dry mouth and insomnia.^[4]

The above-mentioned studies report increases of the cardiac rhythm, and one also increases of diastolic and systolic blood pressures.

This active molecular is a selective norepinephrine reuptake inhibitor that developed for ADHD (attention-deficit hyperactivity disorder) and as an antidepressant agent originated by Eli Lilly. In Jan 2014, Eli Lilly completed a phase III extension trial in adjunctive treatment of major depressive disorder in Japan. In Jul 2015, Eli Lilly terminates phase II/III trial in Attention deficit hyperactivity disorder.

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