Buy Atomoxetine (Strattera) Cas 83015-26-3
Atomoxetine, sold under the brand name Strattera,[11] is a selective norepinephrine reuptake inhibitor (SNRI) medication used to treat attention deficit hyperactivity disorder (ADHD)[12] and, to a lesser extent, cognitive disengagement syndrome (CDS).[13][14][15] It may be used alone or along with psychostimulant medication.[16][17] It enhances the executive functions of self-motivation, sustained attention, inhibition, working memory, reaction time,[18] and emotional self-regulation.[19][20] Use of atomoxetine is only recommended for those who are at least six years old.[12] It is taken orally.[12] The effectiveness of atomoxetine is comparable to the commonly prescribed stimulant medication methylphenidate.[21][22][23][24]
Common side effects of atomoxetine include abdominal pain, decreased appetite, nausea, feeling tired, and dizziness.[12] Serious side effects may include angioedema, liver problems, stroke, psychosis, heart problems, suicide, and aggression.[12][25] There is a lack of data regarding its safety during pregnancy; as of 2019, its safety during pregnancy and for use during breastfeeding is not certain.[26][27]
It was approved for medical use in the United States in 2002.[12] In 2023, it was the 161st most commonly prescribed medication in the United States, with more than 3 million prescriptions.[28][29]
Medical uses
Atomoxetine is indicated for the treatment of attention deficit hyperactivity disorder (ADHD).[4]
Attention deficit hyperactivity disorder
Atomoxetine is approved for use in children, adolescents, and adults.[4] However, its efficacy has not been studied in children under six years old.[7] One of the primary differences with the standard stimulant treatments for ADHD is that it has little known abuse potential.[7] Meta-analyses and systematic reviews have found that atomoxetine has comparable efficacy and equal tolerability to methylphenidate in children and adolescents. In adults, efficacy and tolerability are equivalent.[21][22][23][24]
While its efficacy may be less than that of lisdexamfetamine,[30] there is some evidence supporting its use in combination with stimulants.[16] Doctors may prescribe non-stimulants including atomoxetine when a person has bothersome side effects from stimulants; when a stimulant was not effective; in combination with a stimulant to increase effectiveness;[31][32] when the cost of stimulants is prohibitive; or when there is concern about the abuse potential of stimulants in a patient with a history of substance use disorder.
Atomoxetine alleviates ADHD symptoms through norepinephrine reuptake inhibition and by indirectly increasing dopamine in the prefrontal cortex,[33] sharing 70–80% of the brain regions with stimulants in its produced effects.[34]
Unlike α2-adrenergic receptor agonists such as guanfacine and clonidine, atomoxetine’s use can be abruptly stopped without significant withdrawal symptoms being observed.[7]
The initial therapeutic effects of atomoxetine usually take 1 to 4 weeks to become apparent.[6][35][36] A further 2 to 4 weeks may be required for the full therapeutic effects to be seen.[37][35] Incrementally increasing response may occur up to 1 year or longer.[36][38] The maximum recommended total daily dose in children and adolescents is 70 mg and adults is 100 mg.[4]
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