Buy THPO (4-5-6-7-tetrahydroisoxazolo) Cas 53602-00-9

THPO, also known as 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3(2H)-one, is a relatively weak GABA reuptake inhibitor with some glial selectivity.^[1][2] It is a synthetic and conformationally restrained analogue of the GABA_A receptor agonist and weak GABA reuptake inhibitor muscimol (found in Amanita muscaria).^[1] Unlike muscimol however, THPO is a selective GABA reuptake inhibitor and lacks GABA_A receptor affinity.^[3][2] The drug penetrates into the brain in newborn mice, but shows only very limited central penetration in animals with fully developed brains.^[2] Other structurally related selective GABA reuptake inhibitors include guvacine, nipecotic acid, and tiagabine.^[1][2]