Buy Guvacine (tetrahydropyridine) Cas 498-96-4

Guvacine is a tetrahydropyridine alkaloid found in areca nuts.^[1] It is the N–demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both of which are also found in areca nuts as well. The compound is a potent and selective GABA reuptake inhibitor via GABA transporter 1 (GAT-1) inhibition.^[2]^[3]^[4] It shows poor blood–brain barrier penetration.^[5] Lime hydrolyzes guvacoline to guvacine.^[6]

References

Voigt V, Laug L, Zebisch K, Thondorf I, Markwardt F, Brandsch M (April 2013). “Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1)”. The Journal of Pharmacy and Pharmacology. 65 (4): 582–590. doi:10.1111/jphp.12006. PMID 23488788. S2CID 27577546.
Krogsgaard-Larsen P (June 1980). “Inhibitors of the GABA uptake systems”. Molecular and Cellular Biochemistry. 31 (2): 105–121. doi:10.1007/BF00240816. PMID 6251361.
Krogsgaard-Larsen P, Frølund B, Frydenvang K (August 2000). “GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects”. Current Pharmaceutical Design. 6 (12): 1193–1209. doi:10.2174/1381612003399608. PMID 10903390.
Soudijn W, van Wijngaarden I (October 2000). “The GABA transporter and its inhibitors”. Current Medicinal Chemistry. 7 (10): 1063–1079. doi:10.2174/0929867003374363. PMID 10911018.
Armer RE (February 2000). “Inhibitors of mammalian central nervous system selective amino acid transporters”. Current Medicinal Chemistry. 7 (2): 199–209. doi:10.2174/0929867003375380. PMID 10637362.
Johnston GA, Krogsgaard-Larsen P, Stephanson A (December 1975). “Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake”. Nature. 258 (5536): 627–628. Bibcode:1975Natur.258..627J. doi:10.1038/258627a0. PMID 1207742. S2CID 4147760.

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