Buy Dihydromuscimol (4-5-dihydromuscimol) Cas 72241-46-4

Dihydromuscimol (DHM), or 4,5-dihydromuscimol, is a synthetic GABA_A receptor agonist and GABA reuptake inhibitor which was derived from the Amanita muscaria constituent muscimol.^[1][2][3] The compound is a dihydroisoxazole derivative.^[4]

The compound has two enantiomeric forms. (S)-Dihydromuscimol is a selective and extremely potent GABA_A receptor agonist, while (R)-dihydromuscimol is a GABA reuptake inhibitor and a weak GABA_A receptor agonist.^[5][6][7][8] Dihydromuscimol is equipotent to muscimol as a GABA_A receptor agonist but is more potent as a GABA reuptake inhibitor.^[7][8] However, (S)-dihydromuscimol is slightly more potent than muscimol as a GABA_A receptor agonist.^[6] The enantiomer is the most potent GABA_A receptor agonist that has been discovered as of 2004.^[1][8]

Dihydromuscimol was first described in the scientific literature by Povl Krogsgaard-Larsen and colleagues by 1979.^[4][3] The aminomethyl side chain of dihydromuscimol may be just as susceptible to metabolism as that of muscimol, and hence the drug has not been extensively used in animal studies.^[9]