Buy Trihexyphenidyl (Artane) Cas 144-11-6

Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson’s disease. It was approved by the FDA for the treatment of Parkinson’s in the US in 1949.^[2][3]

Trihexyphenidyl is a therapeutic alternative on the World Health Organization’s List of Essential Medicines.^[4]

Trihexyphenidyl is used for the symptomatic treatment of Parkinson’s disease in mono and combination therapy.^[5]

Trihexyphenidyl has also been prescribed for essential tremor and akathisia.^[6][7]

In pediatrics, it has been used for children with dystonia due to cerebral palsy,^[8][9][10] and to control drooling.^[11]

In organophosphate poisoning, trihexyphenidyl is a more effective antidote than atropine to counteract the cholinergic crisis, seizures, and neuropathology.^[12]

Contraindications include according to the Therapeutic Goods Administration Australia from 2022:^[13]

• • • Hypersensitivity to trihexyphenidyl
    • Narrow angle glaucoma
    • Ileus (disruption of the normal propulsive ability of the intestine)
    • Caution: People with obstructive diseases of the urogenital tract, people with a known history of seizures and those with potentially dangerous tachycardia

Dose-dependent side effects are frequent, but typically lessen over time as the body adapts to the medication. All of the following symptoms considered, Artane has been shown to dramatically and consistently improve neurologic defects in people aged 16–86 over the course of five years.^[14] People who are older or who have psychiatric conditions may become confused or develop delirium. Side effects include but are not limited to:^[15]

• • Central nervous system: drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl may be abused due to a short acting mood-elevating and euphoric effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold.