Buy Benzatropine (benztropine) Cas 86-13-5

Benzatropine (INNTooltip International Nonproprietary Name),^[3] known as benztropine in the United States and Japan,^[4] is a medication used to treat movement disorders like parkinsonism and dystonia, as well as extrapyramidal side effects of antipsychotics, including akathisia.^[5] It is not useful for tardive dyskinesia.^[5] It is a centrally acting anticholinergic and antihistamine, taken by mouth or by injection into a vein or muscle.^[5] Benefits are seen within two hours and last for up to ten hours.^[6][7]

Common side effects include dry mouth, blurry vision, nausea, and constipation.^[5] Serious side effect may include urinary retention, hallucinations, hyperthermia, and poor coordination.^[5] It is unclear if use during pregnancy or breastfeeding is safe.^[8] Benzatropine is an anticholinergic which works by blocking the activity of muscarinic acetylcholine receptors.^[5] The drug also has antihistamine and dopamine reuptake inhibitor activity.^[1]

Benzatropine was approved for medical use in the United States in 1954.^[5] It is available as a generic medication.^[5] In 2020, it was the 229th most commonly prescribed medication in the United States, with more than 2 million prescriptions.^[9][10] It is sold under the brand name Cogentin among others.^[5]

Benzatropine is used to reduce extrapyramidal side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson’s disease. It improves tremor, and may alleviate rigidity and bradykinesia.^[11] Benzatropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

These are principally anticholinergic:

• Dry mouth
• Blurred vision
• Cognitive changes
• Drowsiness
• Constipation
• Urinary retention
• Tachycardia
• Anorexia
• Severe delirium and hallucinations (in overdose)

While some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia (a long-term side effect of antipsychotics),^[12][13] other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia,^[14] although symptoms may be worsened.^[15]

Drugs that decrease cholinergic transmission may impair storage of new information into long-term memory. Anticholinergic agents can also impair time perception.^[16]