Buy Carisoprodol (Soma) Cas 78-44-4

Carisoprodol, sold under the brand name Soma among others, is an oral medication used for musculoskeletal pain.^[8] Effects generally begin within half an hour and last for up to six hours.^[8]

Common side effects include headache, dizziness, and sleepiness.^[8] Serious side effect may include addiction, allergic reactions, and seizures.^[8] In people with a sulfa allergy certain formulations may result in problems.^[8] Safety during pregnancy and breastfeeding is not clear.^[8][9] How it works is not clear.^[8] Some of its effects are believed to occur following metabolic conversion into meprobamate, carisoprodol’s main active metabolite.^[8]

Carisoprodol was approved for medical use in the United States in 1959.^[8] Its approval in the European Union was withdrawn in 2008.^[10] It is available as a generic medication.^[8] In 2019, it was the 343rd most commonly prescribed medication in the United States, with more than 800,000 prescriptions.^[11] In the United States, it is a Schedule IV controlled substance.^[8]

Carisoprodol is meant to be used along with rest, physical therapy and other measures to relax muscles after strains, sprains and muscle injuries.^[12] It comes in tablet format and is taken by the mouth three times a day and before bed.^[12]

The usual dose of 350 mg is unlikely to engender prominent side effects other than somnolence, and mild to significant euphoria or dysphoria, but the euphoria is generally short-lived due to the fast metabolism of carisoprodol into meprobamate and other metabolites; the euphoria derived is, according to new research,^[13] most likely due to carisoprodol’s inherent, potent anxiolytic effects that are far stronger than those produced by its primary metabolite, meprobamate, which is often misblamed for the drug-seeking associated with carisoprodol, as carisoprodol itself is responsible for the significantly more intense central nervous system effects than meprobamate alone. Carisoprodol has a qualitatively different set of effects to that of meprobamate (Miltown). The medication is well tolerated and without adverse effects in the majority of patients for whom it is indicated. In some patients, however, and/or early in therapy, carisoprodol can have the full spectrum of sedative side effects and can impair the patient’s ability to operate a firearm, motor vehicles, and other machinery of various types, especially when taken with medications containing alcohol, in which case an alternative medication would be considered. The intensity of the side effects of carisoprodol tends to lessen as therapy continues, as is the case with many other drugs. Other side effects include: dizziness, clumsiness, headache, fast heart rate, upset stomach, vomiting and skin rash.^[12]

There are 368 drugs known to interact with carisoprodol including 28 major drug interactions.^[14] The interaction of carisoprodol with essentially all opioids, and other centrally acting analgesics, but especially codeine and those of the codeine-derived subgroup of the semisynthetic class (ethylmorphine, dihydrocodeine, hydrocodone, oxycodone, nicocodeine, benzylmorphine, the various acetylated codeine derivatives including acetyldihydrocodeine, dihydroisocodeine, nicodicodeine and others) which allows the use of a smaller dose of the opioid to have a given effect, is useful in general and especially where skeletal muscle injury and/or spasm is a large part of the problem. The potentiation effect is also useful in other pain situations and is also especially useful with opioids of the open-chain class, such as methadone, levomethadone, ketobemidone, phenadoxone and others. In recreational drug users, deaths have resulted from combining doses of hydrocodone and carisoprodol. Another danger of misuse of carisoprodol and opiates is the potential to asphyxiate while unconscious.^{[citation needed]}