Buy Quetiapine (Seroquel) Cas 111974-69-7

Quetiapine (/kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, and major depressive disorder.^[10][11] Despite being widely prescribed as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side effects.^[12] It is taken orally.^[10]

Common side effects include sedation, fatigue, weight gain, constipation, and dry mouth.^[10] Other side effects include low blood pressure with standing, seizures, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome.^[10] In older people with dementia, its use increases the risk of death.^[10] Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth.^[10] Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine.^[10]

Quetiapine was developed in 1985 and was approved for medical use in the United States in 1997.^[3][10][13] It is available as a generic medication.^[14] In 2023, it was the most prescribed antipsychotic and 60th most commonly prescribed medication in the United States, with more than 10 million prescriptions.^[15][16] It is on the World Health Organization’s List of Essential Medicines.^[17]

The drug is typically among two antipsychotics (the other being olanzapine) to have superior efficacy for the treatment of bipolar disorder. Quetiapine is one of only two antipsychotics (the other is cariprazine) that produce equal efficacy as standalone therapies for mixed manic-depressive mood swings as they do in combination with an SSRI antidepressant. However, it is less potent than clozapine, amisulpride, olanzapine, risperidone, and paliperidone in alleviating psychotic symptoms or treating schizophrenia.

Quetiapine is primarily used to treat schizophrenia and bipolar disorder.^[18] It targets both positive and negative symptoms of schizophrenia.^[19]

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

In a 2013 comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. It was 13–16% more effective than ziprasidone, chlorpromazine, and asenapine and approximately as effective as haloperidol and aripiprazole.^[21]

There is tentative evidence of the benefit of quetiapine versus placebo in schizophrenia; however, definitive conclusions are not possible due to the high rate of attrition in trials (greater than 50%) and the lack of data on economic outcomes, social functioning, or quality of life.^[22]

It is debatable whether, as a class, typical or atypical antipsychotics are more effective.^[23] Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages.^[24] While quetiapine has lower rates of extrapyramidal side effects, there is greater sleepiness and rates of dry mouth.^[22]

A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious than olanzapine and risperidone; produce fewer movement related side effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and aripiprazole. It found that quetiapine produces suicide attempts; death; QTc prolongation, low blood pressure; tachycardia; sedation; gynaecomastia; galactorrhoea, menstrual irregularity, and decline in white blood cell count at a rate similar to first-generation antipsychotics.^[25]