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Clomipramine ( Anafranil ) is a psychotropic drug used as an antidepressant and anxiolytic . It belongs to the class of tricyclic antidepressants . It was developed in the 1960s by the Swiss manufacturer Geigy (now Novartis ) and has remained in use worldwide ever since. It acts as a reuptake inhibitor of certain neurotransmitters , serotonin and norepinephrine , in the central nervous system [ 3 ] .
Therapeutic indications
- Depression
- Obsessive-compulsive disorder (OCD) [ 4 ]
- Panic attacks
- Narcolepsy
- Premature ejaculation
- Chronic pain
- nocturnal enuresis
In most cases, the full effect of this psychotropic drug is only felt after two to three weeks. In the case of OCD, it takes two months or more.
Miscellaneous
Clomipramine is on the World Health Organization ‘s list of essential medicines (list updated in) [ 5 ] .
See also
Related articles
External links
- Swiss Compendium of Medicines: Products containing Clomipramine [ archive ]
Notes and references
(en) This article is partially or entirely derived from the English Wikipedia article entitled ” Clomipramine ” ( see the list of authors ) .
- Molar mass calculated from ” Atomic weights of the elements 2007 [ archive ] ” , on www.chem.qmul.ac.uk.
- “ Public Database of Medicines [ archive ] ”, on base-donnees-publique.medicaments.gouv.fr (accessed on)
- (en) « Clomicalm [ archive ] »
, on the European Medicine Agency , (accessed on) - (in) Albert U, Aguglia E, Maina G, Bogetto F, “ Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study ”, J Clin Psychiatry , vol. 63, no . 11,, p. 1004–9 ( PMID 12444814 , read online [ archive ] )
- WHO Model List of Essential Medicines, 18th list [ archive ] , April 2013
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