Buy Desvenlafaxine (Pristiq) Cas 93413-62-8
Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat depression.[4] It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth.[4] It is recommended that the need for further treatment be occasionally reassessed.[4] Studies have shown similar effectiveness compared to its parent compound venlafaxine.[5][6]
Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems.[4] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure.[4] There is a high risk of withdrawal syndrome which may occur if the dose is decreased or the medication is completely stopped.[4][7] It is unclear if use during pregnancy or breastfeeding is safe.[8]
Desvenlafaxine was approved for medical use in the United States in 2008.[4] In Europe its application for use was denied in 2009, although has since been approved for Spain and Germany.[9] In 2023, it was the 189th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[10][11]
Medical uses
Desvenlafaxine is primarily used as a treatment for major depressive disorder.[12] Use has only been studied up to 8 weeks.[4] Multiple studies have shown comparable effectiveness to venlafaxine as well as a lower rate of nausea.[5][6] Other studies have shown it to be either less effective[9] or more effective[13] than venlafaxine.
Doses of 50 to 400 mg/day appear effective for major depressive disorder, although no additional benefit was demonstrated at doses greater than 50 mg/day, and adverse events and discontinuations were more frequent at higher doses.[14]
Desvenlafaxine improves the HAM-D17 score[15] and measures of well-being such as the Sheehan Disability Scale (SDS) and 5-item World Health Organization Well-Being Index (WHO-5).[16]
Desvenlafaxine may also be prescribed off label for the treatment of hot flashes.[17] A review of studies in 2014 found a 55% – 69% reduction in number of hot flashes.[18]
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