Buy Dexmedetomidine (Precedex) Cas 113775-47-6

Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation.^[4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses.^[10][11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder.^[5] It is administered as an intravenous solution or as a buccal or sublingual film.^[1]

Similar to clonidine, dexmedetomidine is a sympatholytic drug that acts as an agonist of α₂-adrenergic receptors in certain parts of the brain.^[12] It was developed by Orion Pharma.

Studies suggest dexmedetomidine for sedation in mechanically ventilated adults may reduce time to extubation and ICU stay.^[13][14]

Compared with other sedatives, some studies suggest dexmedetomidine may be associated with less delirium.^[15] However, this finding is not consistent across multiple studies.^[14] At the very least, when aggregating many study results together, use of dexmedetomidine appears to be associated with less neurocognitive dysfunction compared to other sedatives.^[16] Whether this observation has a beneficial psychological impact is unclear.^[15] From an economic perspective, dexmedetomidine is associated with lower ICU costs, largely due to a shorter time to extubation.^[17]

Dexmedetomidine can also be used for procedural sedation such as during colonoscopy.^[18] It can be used as an adjunct with other sedatives like benzodiazepines, opioids, and propofol to enhance sedation and help maintain hemodynamic stability by decreasing the requirement of other sedatives.^[19][20] Dexmedetomidine is also used for procedural sedation in children.^[21]

It can be used for sedation required for awake fibreoptic nasal intubation in patients with a difficult airway.^[22]

It has also been used as an adjunct infusion during general anesthesia. In this application, it has been shown to decrease post-operative delirium, pain, nausea and opioid use.^{[23][24][25][26]}