Buy Hydroxyzine(antihistamine) Cas 68-88-2

Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication.^[15] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness).^[15] It is used either by mouth or injection into a muscle.^[15]

Hydroxyzine works by blocking the effects of histamine.^[16] It is a first-generation antihistamine in the piperazine family of chemicals.^[15][7] Common side effects include sleepiness, headache, and dry mouth.^[15][16] Serious side effects may include QT prolongation.^[16] It is unclear if use during pregnancy or breastfeeding is safe.^[15]

It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year.^[15][17] In 2023, it was the 39th most commonly prescribed medication in the United States, with more than 15 million prescriptions.^[18][19]

This article relies excessively on references to primary sources. Please improve this article by adding secondary or tertiary sources. Find sources: “Hydroxyzine” – news · newspapers · books · scholar · JSTOR (December 2023) (Learn how and when to remove this message)

Hydroxyzine is used in the treatment of itchiness, anxiety, and nausea due to motion sickness.^[15]

A systematic review concluded that hydroxyzine outperforms placebo in treating generalized anxiety disorder. Insufficient data were available to compare the drug with benzodiazepines and buspirone.^[20]

Hydroxyzine can also be used for the treatment of allergic conditions, such as chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus.^{[medical citation needed]} These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, or urinary tract.^{[21][better source needed]}

Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine, but may, following general anesthesia, potentiate meperidine and barbiturates, and use in pre-anesthetic adjunctive therapy should be modified depending upon the state of the individual.^[21]

Doses of hydroxyzine hydrochloride used for sleep range from 25 to 100 mg.^[22][23][24] As with other antihistamine sleep aids, hydroxyzine is usually only prescribed for short term or “as-needed” use since tolerance to the central nervous system (CNS) effects of hydroxyzine can develop in as little as a few days.^{[25][non-primary source needed]} A major systematic review and network meta-analysis of medications for the treatment of insomnia published in 2022 found little evidence to inform the use of hydroxyzine for insomnia.^[26] A 2023 meta-review concludes that hydroxyzine is effective for inducing sleep onset but less effective for maintaining sleep for eight hours.^[27]