Buy Cyproheptadine ( Periactin) Cas 129-03-3

Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine which is used to treat allergies.^[2] In addition, it has a number of off-label uses, such as treatment of serotonin syndrome and insomnia.^[7][8] The drug is taken orally.^[2]

It is an antihistamine and hence acts as a histamine H₁ receptor antagonist.^[2] In addition to its antihistamine activity, cyproheptadine has anticholinergic, antiserotonergic, antidopaminergic, and local anesthetic properties.^{[2][7][9][10]} These activities make cyproheptadine useful for various additional uses besides antihistamine indications.^[7] As a first-generation antihistamine, cyproheptadine crosses the blood–brain barrier and can produce sedation.^[9] The drug can also produce significant central anticholinergic effects at clinically used doses.^[11][9]

Cyproheptadine was patented in 1959 and came into medical use in 1961.^[12] In 2023, it was the 234th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[13][14]