Buy Chlorphenamine (chlorpheniramine) Cas 132-22-9

Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever).^[2] It is taken orally (by mouth).^[2] The medication takes effect within two hours and lasts for about 4–6 hours.^[2] It is a first-generation antihistamine and works by blocking the histamine H₁ receptor.^[2]

Common side effects include sleepiness, restlessness, and weakness. Other side effects may include dry mouth and wheeziness.^[2]

Chlorpheniramine was patented in 1948 and came into medical use in 1949.^[3] It is available as a generic medication and over the counter.^[2][4]

In 2023, it was the 318th most commonly prescribed medication in the United States, with more than 200,000 prescriptions.^[5]

Chlorphenamine is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties, although phenylpropanolamine was removed from the U.S. market per studies concluding that it increased the risk of stroke in young women.^[6] Vernate was a trade name of one such product available in the U.S. prior to the FDA ban; it was manufactured by Tutag and was among the medications prescribed to Elvis Presley.^[7]

In the drug Coricidin, chlorphenamine is combined with the cough suppressant dextromethorphan. In the drug Cêgripe, chlorphenamine is combined with the analgesic paracetamol (also known as acetaminophen, sold as Tylenol).^[8]

The adverse effects include drowsiness, dizziness, confusion, constipation, anxiety, nausea, blurred vision, restlessness, decreased coordination, dry mouth, shallow breathing, hallucinations, irritability, problems with memory or concentration, tinnitus and trouble urinating.^[2]

Chlorphenamine produces less sedation than other first-generation antihistamines.^[9]

A large study on people 65 years old or older linked the development of Alzheimer’s disease and other forms of dementia to the “higher cumulative” use of chlorphenamine and other first-generation antihistamines, due to their anticholinergic properties.^[10] Chlorphenamine is rated as a “high burden” anticholinergic by experts on a semi-subjective scale.^[11] This is inconsistent with the in vitro experiments showing low affinity to muscarinic acetylcholine receptors (see below).